Search results for "G-QUADRUPLEX STABILIZERS"

showing 2 items of 2 documents

SELECTIVE G-QUADRUPLEX STABILIZERS: SALPHEN-LIKE COMPLEXES WITH ANTIPROLIFERATIVE ACTIVITY

2013

Schiff base complexes derived from N,N!-bridged tetradentate ligands involving N2O2 donor atoms present very favourable features to act as G4 binders. Thus, a series of square-planar and square pyramidal metal complexes, ML2+ (M = Ni, Cu, and Zn), have been synthesized and characterized.

G-QUADRUPLEX STABILIZERS Schiff base complexes hTelo and c-myc G-quadruplexes DNASettore CHIM/03 - Chimica Generale E InorganicaSettore BIO/10 - BiochimicaSettore CHIM/08 - Chimica Farmaceutica
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NiII, and ZnII Schiff Base Complexes: Telomeric G-quadruplex Stabilizers

2014

Recently, NiII and ZnII metal complexes of the ligand Salpyrim have been synthesized and characterized. Their affinity for wild-type h-Telo G-quadruplex DNA and for calf thymus DNA was investigated by UV absorption spectroscopy, circular dichroism and viscometry. The data collectively suggest that both complexes bind effectively to G-quadruplexes by direct end-stacking, stabilizing the oligonucleotide secondary structure. The two complexes are also typical B-DNA intercalators. Remarkably, their binding constants, Kb, with the G4s structures are about 10 fold higher than those with B-DNA, highlighting the selectivity. Experiments to evaluate the biological activity of the two complexes again…

Telomeric G-quadruplex Stabilizers c-Myc c-Kit Schiff base complexes Salphen-like metal complexesSettore CHIM/03 - Chimica Generale E InorganicaSettore BIO/10 - BiochimicaSettore CHIM/08 - Chimica Farmaceutica
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